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Efficacy and Safety of SAR292833 Administration for 4 Weeks in Patients with Chronic Peripheral Neuropathic Pain (Alchemilla)

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The aging process is marked by a persistent dysregulation between pro-oxidant and antioxidant mechanisms, resulting in the excessive production of ROS that hinder eNOS functionality, diminish NO bioavailability, and exacerbate endothelial dysfunction (19)

The second important limitation is predominantly due to the inherent differences between human and rat physiology, rendering the translatability of the findings to humans uncertain

Lower TMAO levels in both males and females were also associated with consuming a Mediterranean diet (157)