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Interestingly, TFRC knockout mice exhibited decreased symptoms of PF following induction with bleomycin [24]

Under prolonged oxidative stress, NADPH binds to the enzyme and stabilizes the structure and protects catalase from inactivation

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218,219 Targeting H 2 S biosynthesis The inhibition of H 2 S biosynthesis has been shown to sensitise cancer cells to chemotherapy, as it disturbs the mitochondrial equilibrium by impairing bioenergetics