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Din MO, Danino T, Prindle A, Skalak M, Selimkhanov J, Allen K, et al

"IL-6 in inflammation, immunity, and disease

In response to stressful conditions, it trimerizes, translocates into the nucleus, binds to the heat shock element of target genes and activates the transcription of HSPs, including HSP70/90 (Noble and Shen, 2012)

These observations are complemented by fluorescence microscopy studies using the ratiometric dye Fura2-AM to measure intracellular Ca2+ levels in cultured cortical neurons

PNC-27 is a synthetic 32aminoacid peptide containing an HDM2binding domain linked to a membranepenetrating sequence, studied preclinically for its selective cytotoxicity toward cancer cells expressing abnormal p53/HDM2 complexes [1] [2]