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Immunofluorescence analysis demonstrated FOXO4 nuclear accumulation in aortic tissues of D-galactose-induced aging mice (Supplementary Figure S1B)

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Epigenetic regulation of NK cells by chromatin modifiers has previously been linked to methyltransferase EZH2 (11, 12), demethylases KDM5A (13), and JMJD3 (14), and the deubiquitinase MYSM1 (15)