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Absolute deficiency occur up to 6% of those aged 60 years and older, whereas marginal deficiency occur in close to 20% of patients in later life ( Pernicious anemia is an autoimmune gastritis resulting from the destruction of gastric parietal cells and consequent impairment of intrinsic factors secretion to bind the ingested vitamin B12

10.3390/ijms21197391 48 ChouR.BaisdenJ.CarrageeE

secretory cells, were always negative for NUPR1 whereas NUPR1-positive cells were positive for p63 (basal cell marker) or acetylated tubulin (ciliated cell marker, Fig