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In conclusion, on the basis of these studies, this review speculated that there may be two mechanisms of ferroptosis leading to obesity: (i) In the autonomic nervous system, vagus and parasympathetic nerves in some organs or tissues may be affected by ferroptosis and become dysfunctional, while the inflammatory factors released from adipocytes lead to excessive sympathetic activation and hypothalamic neuronal ferroptosis which promotes the development of obesity through a series of processes

Thus, Scd1/2 (stearoyl CoA desaturase-1/2), and Ptgis (prostaglandin I2 synthase) located in the endoplasmic reticulum, belong to the unsaturated fatty acid biosynthetic process pathway catalyzing reactions involved in the synthesis of cholesterol, steroids, and other lipids 35

Comparative genomic mapping implicates LRRK2 for intellectual disability and autism at 12q12, and HDHD1, as well as PNPLA4, for X-linked intellectual disability at Xp22.31

Unlike many single-target agents, SFNs ability to simultaneously engage multiple vulnerability nodes in cancer cells reduces the likelihood of resistance development and enhances its therapeutic potential

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