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doi: 10.1038/s41419-023-06042-1 68 KeldsenNHavsteenHVergoteIBertelsenKJakobsenA

Defective autophagy reduces lipid clearance and promotes the accumulation of lipotoxic species (e.g., ceramides and lysophosphatidylcholine), which activate innate immune pathways, including TLRs and the NLRP3 inflammasome, in Kupffer cells and hepatic stellate cells (HSCs)

95% CI: 0.064.22

These results implied a dosage trade-off effect, whereby an excessively high concentration of SL might shift from protection to a potential inhibitory effect on protein homeostasis

Categorical variables were reported as percentages, and between-group comparisons were performed with the 2 test or Fishers exact test