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SHMT catalyzes the conversion of serine to glycine and is regulated by c-MYC , an oncogene that controls the transcription of 15% of human genes [123, 137, 138]

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Moreover, a GWAS has linked specific risk variants associated with glutamate metabolism to increased cortical glutamate concentrations and poor disease outcomes in MS patients (91)

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Its characteristic absorption mode and proven efficacy suggest it could effectively address B12 deficiency in a broad range of populations, including those with gastrointestinal conditions and pernicious anemia, thereby supporting overall health