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In the most severe cases, dogs with hereditary conditions that affect cobalamin absorption if left untreated will die due to metabolic problems and immunodeficiency

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doi: 10.1016/j.ejvs.2009.05.007

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Primary comparison of the 80 mg TID group to the 5 mg TID group yielded the HR (99.7% CI) = 0.51 (0.22, 1.21)

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