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demonstrated that the combination of cisplatin with nab-paclitaxel/gemcitabine resulted in improved clinical outcomes, including mOS of 19.2 months and a mPFS of 11.8 months in patients with advanced BTC (NCT02392637) [33], indicating enhanced efficacy and potential to mitigate resistance

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These pathogens disrupt oxidative phosphorylation, elevate mitochondrial ROS, and alter mitochondrial dynamics, leading to depolarized membrane potential and mtDNA release (Xian et al., 2022)