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Elevated MMA levels in patients with vitamin B12 deficiency can contribute to myelin damage (myelopathy) and, consequently, peripheral and autonomic neuropathy ( Cobalamin deficiency can lead to neurological manifestations such as progressive axonal demyelination, impaired peripheral and sensory nerve function, areflexia, loss of proprioception and vibration sensitivity, and subacute combined spinal cord degeneration (70)

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Oroxylin a promotes PGC-1/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease