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Ferroptosis-associated pathways in stroke Over previous years, ferroptosis has become an area of interest for researchers (12)

Pak, N.J

Acknowledgements This work was supported by the National Key R&D Program of China (2022YFD1600505)

Since the reduction of cystine to cysteine consumes nicotinamide adenine dinucleotide phosphate (NADPH), a reducing equivalent, SLC7A11-overexpressing cells with high rates of cystine import require large amounts of NADPH to constantly reduce cystine to cysteine and to maintain intracellular cystine at nontoxic levels