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Side effects and safety of the combination The side-effect profile of the combination is essentially the union of the individual profiles, with no documented additive concerns at typical clinical doses

Recombinant human insulin-like growth factor-I enhances whole body protein anabolism and significantly diminishes the protein catabolic effects of prednisone in humans without a diabetogenic effect

Renal impairment reduces B12 excretion, leading to accumulation

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