glutathione signaling pathway Biosynthesis of (GSH) from amino acid precursors GLUTATHIONE SYNTHESIS - PMC

Pharmacokinetic information is not available as to whether or not N-acetylcysteine crosses the blood-brain barrier or placenta, or into breast milk

Also, crossing the BBB to reach the tumor site is also a critical issue for antioxidants

[PubMed 3414694] 1185

Biliary excretion of a glutathione conjugates of busulfan and 1, 4-diiodobutane in the rat

GSH can be exhausted via inhibiting SLC7A11 by traditional drugs (e.g., sorafenib and sulfasalazine (SAS)) or novel compounds (e.g., erastin), thus inducing ferroptosis (Zhang et al., 2018), tumor protein 53 (TP53) (Jiang et al., 2015), nuclear factor E2 related factor 2 (NFE2L2/Nrf2) (Sun et al., 2016)