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doi: 10.1016/j.freeradbiomed.2012.04.020 277 ZengZGaoZLZhangZPJiangHBYangCQYangJet al

They identified 260 itaconate-modified cysteines and found that itaconate inhibits glycolysis primarily by silencing glycolytic enzymes (e.g., ALDOA) to alleviate the inflammatory response in activated macrophages and revealed the negative feedback between glycolysis and the anti-inflammatory mechanism originating from itaconate