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S15 and Supplementary Table S6) RMC liver metastases have increased transcriptional similarity to myeloid cells after treatment with nivolumab plus ipilimumab To measure whether tumor cells treated with ICT are undergoing cell state changes, we utilized the single-cell entropy (SCENT) 21 algorithm to quantify tumor cell entropy, a robust proxy for a cells differentiation potential

Histamine and serotonin, released following mast cell degranulation, are two preformed mediators with known roles in mediating itch, pain, diarrhoea and visceral malaise 22,31,32,33