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Methylation Capacity Second, NNMT inhibition affects cellular methylation capacity: SAM is required for hundreds of methyltransferase reactions throughout the cell, and NNMT's consumption of SAM can deplete this critical resource, while the SAH produced by NNMT is a potent product inhibitor of many methyltransferases

The slides were air-dried and examined at 400 magnification under a light microscope

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Li Y, Zhang Q, Peng B, Shao Q, Qian W, Zhang JY