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Metabolism/immunity dual-regulation thermogels potentiating immunotherapy of glioblastoma through lactate-excretion inhibition and PD-1/PD-L1 blockade

Discuss your full health history with our physician if you: Are pregnant, planning pregnancy, or breastfeeding Have a personal or family history of medullary thyroid carcinoma (MTC) Have multiple endocrine neoplasia syndrome type 2 (MEN 2) Have a history of pancreatitis, gallbladder disease, or severe GI disorder Have an eating disorder (active or recent) Are on insulin or sulfonylureas without prior medical adjustment Lose Fat

The IRB approval number: is IRCM-2021304

Moreover, ferroptosis can propagate through intercellular mechanisms involving the release of damage-associated molecular patterns (DAMPs), dysregulation of immune checkpoints, and exosome-mediated signaling, collectively driving microglial activation, T-cell infiltration, and bloodbrain barrier disruption, culminating in systemic immune imbalance

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