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Marbois B

Investigation of heterogeneity Our results showed that there was no significant between-study heterogeneity for studies measuring GSSG concentrations, whereas the other 34 oxidative stress-related markers showed significant between-study heterogeneities

PK parameters such as clearance rate (Cl), distribution volume (Vdss), terminal half-life through IV dosing (T1/2), and bioavailability (F%) were calculated following the standard formula

Then, 10 L of the supernatant was dropped into the reaction pore of the Mouse 8-OHdG ELISA KIT (Y-S Bio-Technology, Shanghai, China) and mixed with 40 L sample diluent

Mitochondria are the primary source of intracellular ROS, and ROS modulator 1 is one of the key mitochondrial proteins involved in ROS production 36