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High doses of ursodeoxycholic acid up-regulate the expression of placental breast cancer resistance protein in patients affected by intrahepatic cholestasis of pregnancy

Beyond the production of ROS, macrophages also employ an array of directly antimicrobial mechanisms, e.g., the generation of reactive nitrogen species (RNS) in the phagosome and the delivery of cathepsins and other hydrolases into maturing phagosomes [59,225,226,227,228,229,230]

In practice, unformulated CoQ10 achieves oral bioavailability as low as 4% because its crystalline structure and high molecular weight severely restrict its dispersion in the gastrointestinal tract

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