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[20] Acute Intermittent Porphyria (AIP) AIP (OMIM #176000), also the most prevalent type of acute porphyria, is a metabolic disorder precipitated by mutations in the hydroxymethylbilane synthase (HMBS) gene that result in overproduction of porphyrin precursors ALA and porphobilinogen (PBG) (Figure 1B)

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Lancet Public Health 3: e419e428 Sena L, Li S, Jairaman A, Prakriya M, Ezponda T, Hildeman D, Wang CR, Schumacker P, Licht J, Perlman H et al (2013) Mitochondria are required for antigenspecific T cell activation through reactive oxygen species signaling

10.1021/nn102845t 14 AtamnaH.Paler-MartnezA.AmesB

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