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A growing body of evidence has demonstrated that kynurenine pathway activity is generally increased in COPD and its acute exacerbations: the KYN/TRP ratio has been found to be elevated in peripheral blood or respiratory samples in several studies and is associated with inflammatory markers, suggesting a potential role of this pathway in the inflammation-metabolism crosstalk in COPD

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Additionally, we expected that the prodrugs Lys-MDMA and Lys-MDA would show longer times to onset and maximal concentration of the active substance in plasma and associated longer times to effect onset and maximal peak responses compared with MDMA and MDA, respectively

To minimize the formation of photoactive byproducts, the culture medium was replaced with Hanks Balanced Salt Solution (HBSS