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Finally, these data point to the utility of analyzing the TME very early after T cell infusion and may have a significant effect on designing next-generation autologous and off-the-shelf therapies

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In line, lactate also accumulated to a higher extent in the culture medium of Gclc fl/fl Mb1-Cre + FoB as compared to control cells (Fig

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Gene expression programs controlled by canonical and non-canonical TGF- signaling pathways may provide tumor-suppressive or tumor-promoting functions depending on the tumor type and the stage of tumor progression 22