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In nature, the mating of haploid cells to form diploid cells is most often between members of the same clonal population and out-crossing is uncommon

This allows for optimal absorption and provides antioxidant support for the oxidative stress that occurs during daily activities and exercise

Further mechanistic studies have found that treatment with TMZ promoted cardiac Nrf2 expression, indicating that TMZ enhanced the clearance of oxidative stress by activating the GSH system through the Nrf2 signaling pathway [210]

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