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Thus, only at the moments in which a high energy expenditure occurs is insulin used and only there does it behave as in the rest of the body

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In vivo, Se/LDH@PEG-M effectively reduced osteophyte formation, ameliorated subchondral bone microarchitecture, attenuated cartilage degradation, alleviated synovial inflammation, and reshaped the synovial microenvironment in OA mice

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The following antibodies were used in this study with clones, venders and fluorochrome as indicated: CD45 (30-F11, Biolegend, BV510), EpCAM (G8.8, Biolegend, BV711), CD133 (315-2C11, Biolegend, PEDazzle594) and Podoplanin (8.1.1, Biolegend, PE-Cy7)

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