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With developments in novel skin permeation enhancing methods such as microneedles and laser, copper compounds can potentially be used on skin for cosmeceutical or medicinal purposes 5,11,12

Following a 24 h incubation period with CuCl 2 concentrations ranging from 0.2 to 0.6mmol/l, a significant copper-dependent regulation was detected for four cytokines in the cell culture supernatant of the treated cells

A healed scar remains healed because underlying pathology resolved, while anti-aging collagen stimulation requires ongoing support for maintaining enhanced synthesis above baseline capacity

J Clin Endocrinol Metab 85 : 49084911 Choe YH et al