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[2] The primary role of GSTs is to catalyze the conjugation of glutathione (GSH) with the electrophilic centers of a wide variety of molecules

Various cell functions including signal transduction pathways, host defense against invasive pathogens, autophagy, cellular proliferation and apoptosis are mediated by physiological amounts of ROS [137]

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Psychiatry 38, 3650

These findings detail mechanisms of NRF2-dependent transcriptional regulation, pointing to noncanonical roles that extend beyond augmenting antioxidant capacity