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S., Dhillon, N., Leppert, P., & Segars, J

2016;14:e17-30

Moving forward, greater reliance on human iPSCderived dopaminergic neurons, organoids, and humanized animal models will be essential for derisking translational strategies

Samples were then centrifuged at 15,000 g for 5 min at 4 C, and the supernatant fraction transferred into a new vial

Thioredoxin reductases (TXNRDs) employ NADPH as an electron donor to revert oxidized TXN to a reduced dithiol, the oxidation status of which is critically implicated in regulating various cell behaviors including proliferation and apoptosis 51