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Nimura, K

One potential explanation for this phenomenon is the accumulation of fatty acids in the liver, which may exceed its oxidative capacity

L-arginine synthesis occurs in the liver and kidney, with the kidney functioning to maintain homeostatic plasma levels since the liver processes NO from the diet [187]

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17 Low expression of the copper metabolic gene MURR1 domain 10 induced by ionizing radiation promotes hypoxia-inducible factor-1 (HIF1) nuclear translocation and transcription of ceruloplasmin (CP) and SLC7A11 by inducing intracellular Cu accumulation, which jointly inhibits HCC ferroptosis leading to radioresistance