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A null polymorphism in NQO1 15,16 has been associated with an increased risk of complications related to metabolic syndrome 17,18 and NQO1-null mice develop insulin resistance resulting in a T2D-like phenotype 19

[109] Melatonin is also known to modify many cytokines, including TNF, IL1, IL-2, IL-6, and gamma-interferon, in ways consistent with increased host defense against cancers