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Given the substantial resource demands of drug development, large sample sizes, extended trial durations, and the financial and physiological burden of certain treatments (e.g., monoclonal antibodies targeting A), it is ethically and scientifically imperative to identify patients for whom benefit is plausible and to avoid unnecessary exposure of those unlikely to respond

It is not a stabilized peptide but a small molecule ERR receptor agonist, designed from the start for the oral route

To test this, we first examined the effect of Cyss deprivation on the expression of exogenous full-length NRF2 (NRF2-FL) and NRF2-N89 and found that only the NRF2-N89 deletion mutant is insensitive to Cyss deprivation, confirming the involvement of KEAP1 in this regulation (Fig

Ademola, J., Ajgaonkar, A., Debnath, T., et al

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