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Simsir IY, Soyaltin UE, Ozgen AG

2017 NNMT knockdown in adipocytes was associated with improved markers of insulin sensitivity and glucose uptake in preclinical in vitro models, linking NNMT to metabolic homeostasis

DHA then suppresses MAPK/NF-B and NLRP3 signalling, limiting pyroptosis and enhancing motor outcomes in SCI models ( Collectively, these studies converge on the NLRP3/caspase-1/GSDMD axis as the main regulator of microglial pyroptosis, yet they intervene at distinct checkpoints