ghk cu wilson's disease contraindication GHK-Cu Side Effects: Safety Evidence & Risk Factors – PlexusDx Wilson disease | Nature Reviews

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Copper directly binds with the lipoylated proteins of the TCA cycle, leading to the aggregation of these lipoylated proteins and disruption of the iron-sulfur cluster proteins and consequently proteotoxic stress [3]

Indeed, contradictory findings suggest that excess Cu 2+ may induce cell death via apoptosis, 249 caspase-independent cell death, or an accumulation of ROS