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doi: 10.1186/s13765-024-00888-5 179

Furthermore, by activating the AMPK signaling pathway, ALA stimulates the production of PGC-1, driving mitochondrial biogenesis

Vitamin C in disease prevention and cure: an overview

This metabolic dysregulation is defined by systemically reduced levels of metabolites such as amino acids and fatty acids, leading to reduced TCA cycle activity and oxidative phosphorylation, which may ultimately be a major contributor to neuropsychiatric symptoms associated with reduced energy, such as fatigue and other cognitive impairments [43, 62]