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doi: 10.1016/j.jaci.2015.09.028 62 McGregorM

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Moreover, respect to unrelated CTRLs, familial CTRL mitochondria depend more on glutamine as a fuel, than on glucose and fatty acids, a pattern which is found in all family members, except the late-stage patient

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In addition, mature myeloid immune cells display altered phenotypes and functions with elevated production of proinflammatory cytokines such as TNF- and IL-6, which are closely related to age-related senescent inflammation, termed senoinflammation