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A study on asymptomatic elderly Chileans demonstrated that a single injection of vitamin B12 improved conductivity in myelinated peripheral nerves and increased serum vitamin B12 levels, although high serum folate levels appeared to impair the response to vitamin B12 supplementation

Ermens AAM, Refsum H, Rupreht J, Spijkers LJM, Guttormsen AB, Lindemans J, Ueland PM, and Abels J (1991)

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Since IDPs/unfolded proteins have larger size and lower packing density than the folded proteins of the same molecular mass, they are characterized by lower sedimentation coefficients