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Additionally, molecular signals such as pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) can cross into the circulation, potentially impacting both the microbiota and CNS function

Recent clinical studies using 1 H-MRS showed that GSH levels in the brains of ALS patients were decreased compared to those of age-matched healthy volunteers [111], and the decreased GSH levels in the motor cortex and corticospinal tract were inversely correlated with the time after diagnosis [112]

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Atkuri, KR, Cowan, TM, Kwan, T, Ng, A, Herzenberg, LA, Herzenberg, LA, Enns, GM 2009, Inherited disorders affecting mitochondrial function are associated with glutathione deficiency and hypocitrullinemia, Proceedings of the National Academy of Sciences , vol