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This topic is vast and constantly updated, above all because flavonoids have multiple pleiotropic properties (they act on different cellular targets and biochemical mechanisms)

Compared to the group treated with Bi@Chi-SCR, the apoptosis rate was high in the group treated with Bi@Chi-DEC, which can indicate the specific function of DEC compared to SCR

Niimura et al., The experimental value of zebrafish as an animal model for in vivo drug discovery has grown rapidly due to their ease of assessment, large clutch size, and ability to recapitulate human disease conditions (MacRae and Peterson, 2007

Morise et al

Administering an antibody blockade against CD28 would inhibit T-cell activation and induce immune tolerance, which is counterproductive in this patient who requires an augmented cytotoxic response to clear his metastatic disease