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Because of two compounds in coffee: cafestol and kahweol, that appear to switch on a liver detox enzyme, at least in lab studies

J Gastroenterol Hepatol 23(Suppl 1):S9S15 Fernandez A, Colell A, Caballero F, Matias N, Garcia-Ruiz C, Fernandez-Checa JC (2009a) Mitochondrial S-adenosyl-L-methionine transport is insensitive to alcohol-mediated changes in membrane dynamics

Vitamin B12 supplementation may be helpful for people at risk of deficiency, such as those on vegan diets, patients with certain gastrointestinal conditions, or those taking metformin