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Acknowledgments The authors would like to thank the University of Iowa Viral Vector Core and Central Microscopy Research Facilityespecially Jian Shaofor technical assistance

The central mechanism of epileptic seizure is the epileptogenesis process which occurs due to an imbalance between inhibitory and excitatory neurotransmitters (Li et al

Brigelius-Floh, R., Traber, M

22-23] Based on these findings, the CAFC disagreed that a skilled person would have believed that the process described in the 779 Patent would be a promising method of eliminating ABUKs