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Mechanism Diagram GHK-Cu vs Growth Peptides (Key Differences) GHK-Cu - Copper binding tripeptide - Acts locally in tissue - Modulates gene expression and ECM remodelling - Not endocrine - Does not elevate GH or IGF-1 GH Secretagogues (e.g., Ipamorelin, Hexarelin, MK-677) - Act via endocrine receptors - Stimulate systemic GH release - Increase IGF-1 - Primarily hormonal These compounds operate in completely different biological domains

Management of the Apical Tumor: May 4, 2013, Minneapolis, MN

PLoS One 2 , e1217 (2007)

Owing to its ubiquitous nature and its role in promoting cell growth, strategies to inhibit IGF1 actions are being pursued as potential adjunctive measures for treating diseases such as short stature, atherosclerosis and diabetes

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