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doi: 10.3390/ijerph16101829 35

Plasma markers of disrupted gut permeability in severe COVID-19 patients

( 2 O 2 , a potent ROS-inducer, and superoxide dismutase (SOD), a natural antioxidant agent, were higher in GO then control OFs, whereas the ROS antagonist glutathione peroxidase (GPX) was reduced, with a reduced ratio between glutathione and oxidized glutathione, suggesting the presence of a remarkable state of oxidative stress ( Glycosaminoglycan Production and Heat Shock Protein 72 Expression in Orbital fibroblasts As mentioned above, the release of GAGs plays an important role in the pathogenesis of GO

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In contrast to other mammals, humans have developed a unique immune system, due to the lack of an innate immune response to HBV (including interferons, interleukins, tumor necrosis factor, etc.) (Wieland et al., 2004)