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Careful infusions of well-chosen nutrients in reasonable doses could, conceivably, confer benefit, he says

Abbreviations ACh: Acetylcholine AKR1B10: Aldo-keto reductase family 1 member B10 AKT/PKB: AKT serine/threonine kinase/Protein kinase B ALK: ALK receptor tyrosine kinase AP- 1: Activator protein 1 APOBEC3: Apolipoprotein B mRNA editing enzyme catalytic subunit 3 AQP4: Aquaporin 4 ARID1 A: AT-rich interaction domain 1A ASCL1: Achaete-scute homolog 1 ATP: Adenosine triphosphate AXL: AXL receptor tyrosine kinase Bcl-xL: B-cell lymphoma-extra large BET: Bromodomain and extraterminal domain BIM: Bcl-2 interacting mediator of cell death BMF: Bcl-2 modifying factor BRAF: B-Raf protooncogene BRD4: Bromodomain containing 4 CAF: Cancer associated fibroblast CDK: Cyclin dependent kinase CREBBP: CREB binding protein CRISPR/Cas9: Clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 CSC: Cancer stem cell CTLA- 4: Cytotoxic T-lymphocyte associated protein 4 DNMT: DNA methyltransferase DTP: Drug-tolerant persister E2 F: E2 factor EGFR: Epidermal growth factor receptor EHMT2 or G9 A: Eukaryotic histone methyltransferases 2 EMT: Epithelial-mesenchymal transition EOMES: Eomesodermin ERK: Extracellular signal regulated kinase EZH2: Enhancer of zeste homolog 2 FAK: Focal adhesion kinase FAM: Fatty acid metabolism FGF: Fibroblast growth factor FGFR: Fibroblast growth factor receptor FOSL2: FOS like 2 FOXM1: Forkhead box protein M1 GATA2: GATA binding protein 2 GIST: Gastrointestinal stromal tumor GSTM3: Glutathione S-transferase mu 3 H3 K9 me3: Histone 3 Lysine 9 trimethylation HDAC: Histone deacetylase HER- 2: Human epidermal growth factor receptor-2 HMT: Histone methyltransferase IFN: Interferon IGFBP2: Insulin like growth factor binding protein 2 IL- 6: Interleukin 6 JUND: JunD proto-oncogene KDM: Lysine demethylase KIT: KIT proto-oncogene KRAS: Kirsten rat sarcoma virus LINE- 1: Long interspersed elements-1 MAPK: Mitogen-activated protein kinase MDSC: Myeloid-derived suppressor cell MED1: Mediator complex subunit 1 MEK: Extracellular signal-regulated kinase MET: MET protooncogene MRD: Minimal/molecule residual disease mSWI/SNF: Mammalian switch/sucrose non-fermentable mTOR: Mechanistic target of rapamycin NF-kB: Nuclear factor kappa B NPC1L1: NPC1 like intracellular cholesterol transporter 1 NRF2: Nuclear factor erythroid 2-related factor 2 NSCLC: Non-small cell lung cancer OGT: O-linked N-acetylglucosamine transferase ORR: Objective response rate OXPHOS: Oxidative phosphorylation PD: Progressive disease PD- 1: Programmed death protein 1 PDAC: Pancreatic duct adenocarcinoma PD-L1: Programmed death-ligand 1 PI3 K: Phosphatidylinositol 3-kinase PKC: Protein kinase C PLA2: PLC4-associated phospholipase A2 PLC4: Phospholipase c 4 POU2 F2: POU class 2 homeobox 2 PRDX: Peroxiredoxin ROS: Reactive oxygen species RTK: Receptor tyrosine kinase SAC: Spindle assembly checkpoint SETDB1/2: SET domain bifurcated histone lysine methyltransferase 1 or 2 SFTPB/C/D: Surfactant protein B/C/D SGK3: Serum- and glucocorticoid-induced kinase 3 SOD2: Superoxide dismutase 2 SOX2: SRY-box transcription factor 2 STAT3: Signal transducer and activator of transcription 3 STING: Stimulator of interferon genes TAM: Tumor-associated macrophage TAZ: PDZ-binding motif TC: Transcriptional cofactor TEAD: TEA domain TET1: Tet methylcytosine dioxygenase 1 TF: Transcription factor TGF-B: Transforming growth factor beta TKI: Tyrosine kinase inhibitor TME: Tumor microenvironment TNF: Tumor necrosis factor TRAIL: Tumor necrosis factor-related apoptosis-inducing ligand TRM: Tissue-resident memory UCHL1: Ubiquitin C-terminal hydrolase L1 YAP: Yes-associated proteins ZEB1: Zinc finger E-box binding homeobox 1 References Balachandran VP, et al

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doi: 10.1038/nm1001-1118

5C, uncropped original western blots Fig