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DALYs and mortality related to obesity are the consequence of the multiple comorbidities spanning from cardiovascular (CV) and metabolic diseases, such as heart failure (HF) and type 2 diabetes (T2D), to many cancers, infertility and respiratory (e.g., obstructive apnea syndrome), cutaneous (e.g

Rapid improvement in glucose control has been associated with a temporary worsening of diabetic retinopathy

In addition, differences in the study objectives in humans and animals are evident

If the reaction worsens past six weeks rather than improving, the cause is likely something other than an adjustment phase