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The correlation between the clinical features collected for each study groups was studied using the Spearmans rank correlation analysis

The scRNA-seq results showed that the expression of YAP/TAZ target genes, which play a central role in mechano-stress responses, was upregulated in LSECs in the pIVCL group, and that connective tissue growth factor (CTGF) was the most greatly upregulated gene in the whole LSEC population and more upregulated in zone 3 LSECs than in zone 1 LSECs

By reducing oxidative stress, glutathione lowers the risk of cancer development

Dimethyl fumarate modulates the activity of the pro-inflammatory transcription factors

It works by stimulating the release of growth hormone-releasing hormone (GHRH) and inhibiting the secretion of somatostatin, which is a hormone that suppresses the release of growth hormone from the pituitary gland