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How Melanin Determines Skin Tone Skin colour is primarily determined by melanin, a pigment produced by specialised cells called melanocytes in the basal layer of the epidermis

[DOI] [PubMed] [Google Scholar] 182.Goncalves-Dias C., Morello J., Semedo V., Correia M.J., Coelho N.R., Monteiro E.C., Antunes A.M.M., Pereira S.A

Co-stimulatory or co-inhibitory signals pathway, immune checkpoints, and the presence of specialized cell populations form the basis of peripheral tolerance, which are determinants for modulating the immune response [30,31,32]