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216 In fact, a high-cholesterol diet (HCD) alone has been shown to promote macrophage infiltration and significantly enhance the growth of CRC tumors

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The PI3K/PTEN/Akt/mTOR signaling pathway is deregulated in numerous cancers leading to altered cellular processes, which makes this axis an attractive target for therapeutic manipulations

In this section, we will elaborate upon the epigenetic modulations introduced by the Wnt pathway that promote cancer initiation as well as progression