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These include: Metformin (used for diabetes or PCOS) Proton Pump Inhibitors (used for acid reflux or GERD) H2 Blockers Birth control pills Certain antibiotics If youre taking these medications long-term, particularly in combination, regular B12 injections might be beneficial

In Farvid et als study, neuropathy was measured using the Michigan Neuropathy Screening Instrument (MNSI), a brief 15-item questionnaire.(10) In Fonseca et als study, neuropathy was assessed objectively as those with a VPT of 2545 volts at the hallux of either leg.(11) Serum B 12 /methylmalonic acid/homocysteine levels were measured at baseline in Fonseca et als study

Higher NAD+ levels and better mitochondrial function mean cells can respond more robustly to anabolic signals