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Trehalose-loaded LNPs enhance mRNA stability and bridge in vitro in vivo efficacy gap

Berger M, Nelson B, Markulev C, Yuen HP, Schfer MR, Mossaheb N, et al

Garcia-Batista ZE, Guerra-Pena K, Cano-Vindel A, Herrera-Martinez SX, Medrano LA

Individuals with lipodystrophy have abnormal body fat distribution, such as depleted fat levels in the face and the extremities, while also having increased amounts of abdominal and intraorgan (visceral) fat