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This is due to the fact that CaiT is an antiporter catalyzing exchange of intracellular and extracellular trimethylammonium compounds such as L-carnitine, crotonobetaine, and -butyrobetaine, while it does not catalyze uniport of L-carnitine out of the E

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294 These results showing lack of CoQ10 efficacy were affirmed in a 2016 meta-analysis of five randomized controlled trials totaling almost 1,000 participants